According to Catholic Relief Services, two of its employees were killed in the troubled Amhara region of north-central Ethiopia.
Chuol Tongyik and Amare Kindeya were shot in their vehicle as they drove back to Addis Ababa from a job.
Unrest and massive anti-government protests have erupted in the Amhara region in recent days, sparked by an official order to dissolve regional special forces.
In the recent Tigray war, these fought alongside federal troops.
Protesters claim that the move will expose them to attacks from neighboring regions.
